Syntest HS

Syntest HS Ingredients: Esterfied Estrogens and Methyltestosterone
Representative Names: Estratest, Estratest HS, Syntest DS, Syntest HS

What are Syntest HS ?
Syntest HS tablets contain estrogen hormones in combination with an androgen hormone. Estrogens are essential for maintaining normal female functions and are normally produced by the ovaries. After menopause, the ovaries decrease their production of these hormones. Estrogens can help relieve symptoms of the menopause (hot flashes, night sweats, mood changes, and vaginal dryness and irritation), and help to prevent the onset of osteoporosis (a loss of bone mass, so that bones become brittle and easily broken). Methyltestosterone, which is an androgen or male-like hormone, is useful in women who have menopause symptoms that have not responded to estrogens alone. Women's bodies naturally contain small amounts of testosterone, and the natural levels of testosterone also decrease with menopause. Occasionally this medication is used for other purposes. Generic esterified estrogens; methytestosterone tablets are available.

What should my health care professional know before I take Syntest HS ?
They need to know if you have any of these conditions:
•asthma
•blood vessel disease, blood clotting disorder, or suffered a stroke
•breast, cervical, endometrial or uterine cancer
•diabetes
•fibroids in the womb, or endometriosis
•heart, kidney or liver disease
•high blood lipids or cholesterol
•high blood pressure
•high level of calcium in the blood
•hysterectomy
•mental depression
•migraine
•porphyria
•tobacco smoker
•vaginal bleeding
•an unusual or allergic reaction to estrogens, methyltestosterone, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding

How should I take Syntest HS ?
Take Syntest HS by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. If the tablets upset your stomach, take them with food or milk. Take your doses at regular intervals; estrogen-methyltestosterone combinations work best when taken at the same time each day. Do not take your medicine more often than directed.

•For all uses of this medicine:
Before starting this medication, read the paper on your prescription provided by your pharmacist or health care professional. This paper will tell you about the specific product you are taking. Make certain you understand the instructions.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a Syntest HS dose ?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose and resume your normal schedule. Do not take double or extra doses.

What drug(s) may interact with Syntest HS ?
•some antibiotics used to treat infections
•barbiturates or benzodiazepines used for inducing sleep or treating seizures (convulsions)
•carbamazepine
•cimetidine
•cyclosporine
•dantrolene
•medications for diabetes
•methotrexate
•grapefruit juice
•griseofulvin
•herbal remedies for menopause or female problems
•hydrocortisone, cortisone, or prednisolone
•isoniazid (INH)
•methotrexate
•mineral oil
•phenytoin
•raloxifene or tamoxifen
•rifabutin, rifampin, or rifapentine
•thyroid hormones
•topiramate
•tricyclic antidepressants, like amitriptyline or imipramine
•warfarin

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking Syntest HS ?
Side effects that you should report to your prescriber or health care professional as soon as possible:
•breakthrough bleeding and spotting
•breast enlargement, tenderness, unusual discharge or milk production
•chest pain
•leg, arm or groin pain
•nausea, vomiting
•severe or frequent headaches
•stomach pain (severe)
•sudden shortness of breath
•swelling of the hands, feet or ankles, or rapid weight gain
•vision or speech problems
•yellowing of the eyes or skin

Side effects that may indicate a need for decrease in dosage of the hormone (report to your prescriber at the next appointment, or earlier if bothersome, do not change your dose without talking to your prescriber):
•change in sexual desire
•hair loss
•hoarseness of voice
•mood changes, anxiety, depression, frustration, anger, or emotional outbursts
•unusual hair growth
•weight gain

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
•mild stomach upset
•increased or decreased appetite
•skin rash or brown spots on the face
•tiredness
•vaginal yeast infection (irritation and white discharge) - report to your prescriber if you have never had one before

What should I watch for while taking Syntest HS ?
Visit your prescriber or health care professional for regular checks on your progress. You should have a complete check-up every 6 months. You will also need a regular breast and pelvic exam and "Pap" smear while on estrogen therapy. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests. If you have any unusual bleeding contact your prescriber or health care professional for advice.

These hormones can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your prescriber or health care professional if you feel you are retaining fluid.

If you have any reason to think you are pregnant; stop taking this medication at once and contact your prescriber or health care professional.

Tobacco smoking increases the risk of getting a blood clot or having a stroke while you are taking estrogen hormones, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist or health care professional.

In women who still have their uterus, estrogens increase the risk of developing a condition (endometrial hyperplasia or overgrowth) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with estrogens lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.

If you are going to have elective surgery, you may need to stop taking your estrogen hormones one month beforehand. Consult your health care professional for advice prior to scheduling the surgery.

Where can I keep Syntest HS ?
Keep out of the reach of children in a container that small children cannot open.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.