ZANOSAR

Who is Zanosar for ?

Your doctor has ordered the drug Zanosar to help treat your illness. The drug is given by injection into a vein. Zanosar is used to treat:

• pancreatic islet cell cancer

Zanosar is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Zanosar is a type of antibiotic that is only used for chemotherapy; it slows or stops the growth of cancer cells in your body. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer you have.

Zanosar also is used to treat carcinoid tumor, carcinoid syndrome, Hodgkin's disease, pancreatic adenocarcinoma, colorectal cancer, hepatoma, pheochromocytoma, epidermoid carcinoma of the lung, lymphocytic lymphoma, Burkitt's lymphoma, acute lymphocytic leukemia, malignant melanoma, and metastatic sarcoma. Talk to your doctor about the possible risks of using Zanosar for your condition.

When should I be careful taking Zanosar ?

Zanosar can cause a decrease in the number of blood cells in your bone marrow. Zanosar also can cause kidney and liver damage. Your doctor will order certain lab tests to check your response to Zanosar. You should know that Zanosar has been associated with the development of other types of cancers. Talk with your doctor about the potential risk of developing a new cancer.

Before taking Zanosar,

• tell your doctor and pharmacist if you are allergic to Streptozocin or any other drugs.
• tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially other cancer chemotherapeutic drugs, phenytoin (Dilantin), and vitamins.
• tell your doctor if you have or have ever had kidney disease.
• you should know that Zanosar may interfere with the normal menstrual cycle (period) in women and may stop sperm production in men. However, you should not assume that you cannot get pregnant or that you cannot get someone else pregnant. Women who are pregnant or breast-feeding should tell their doctors before they begin taking Zanosar. You should not plan to have children while receiving chemotherapy or for awhile after treatments. (Talk to your doctor for further details.) Use a reliable method of birth control to prevent pregnancy. Zanosar may harm the fetus.
• do not have any vaccinations (e.g., measle or flu shots) without talking to your doctor.

Zanosar Side Effects

Side effects from Zanosar are common and include:

• nausea
• vomiting

Tell your doctor if the following symptom is severe or lasts for several hours:

• fatigue

If you experience any of the following symptoms, call your doctor immediately:

• unusual bruising or bleeding
• fever
• chills
• sore throat
• severe nausea or vomiting
• persistent diarrhea or any change in normal bowel habits for more than 2 days
• confusion
• pain at the injection site
• decreased urination

Zanosar can change the amount of minerals and sugar in your blood. Your doctor will order tests to monitor the amount of minerals and sugar in your blood. Last Revised - 6/98.