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There are many different kinds of
arthritis. Treatment varies, depending on the particular cause, how
severe the disease is, which joints are affected, to what degree the
patient is affected, and the person's age, occupation, and daily
activities. Treatment may focus
on eliminating the underlying cause of the arthritis. However, the
cause usually is NOT curable. Treatment therefore aims at reducing
pain and discomfort and preventing further disability. It is
critical to follow the prescribed therapy.
The symptoms are treated as necessary.
They may be helped with simple modifications in daily activities,
along with adequate rest and appropriate forms of exercise. For
example, low impact aerobic exercise (such as swimming)
significantly relieves joint strain. In other cases, more extensive
therapies are needed. Treatment usually consists of exercise, heat
or cold treatments, methods to protect the joints, various
medications, and possibly surgery.
MEDICATIONS:
Medications to reduce joint pain and joint swelling may include
acetaminophen, aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs),
corticosteroids, and other immunosuppressive drugs (drugs that slow
the immune system).
- Acetaminophen
-- recommended by the American College of Rheumatology as the
first line treatment for osteoarthritis. Taken in doses of up to
4 grams a day, it can provide significant relief of arthritis
pain without many of the side effects of the drugs discussed
below. However, do not exceed the recommended doses of
acetaminophen or take the drug in combination with large amounts
of alcohol, because these pose risks for liver damage.
- Aspirin and NSAIDs
-- are available over-the-counter, and are often effective in
combating arthritis pain. Though these medications can be
prescribed in stronger doses by physicians, they may have many
side effects. Therefore, they should not be taken in any amount
without consulting with your health care provider. The most
dangerous side effects of NSAIDs are the formation of stomach
ulcers, bleeding from the digestive tract, and kidney damage.
Patients with kidney or liver disease, or a history of
gastrointestinal bleeding should not take these medicines
without consulting their physicians.
- New prescription
medications -- drugs, such as
Celecoxib and Rofecoxib, treat arthritis pain in a fashion
similar to traditional NSAIDs. However, they seem to cause less
stomach irritation and confer a lower risk of ulcers and
gastrointestinal bleeding. Because these drugs can still effect
the digestive tract and can be toxic to the kidneys, they should
be taken under careful medical supervision.
- Oral glucosamine and
chondroitin -- these form the building
blocks of cartilage, the substance that lines joints. They are
available at health food stores or supermarkets without a
prescription. Early studies indicate that these compounds are
quite safe and may improve symptoms relating to arthritis.
- Corticosteroids (or "steroids")
-- are medications that suppress the immune system and symptoms
of inflammation. They are commonly used in severe cases of
osteoarthritis, and they can be given orally, by injection, or
occasionally injected directly into an affected joint. Steroids
are used to treat autoimmune forms of arthritis but should be
avoided in infectious arthritis. Steroids have multiple side
effects, including upset stomach and gastrointestinal bleeding,
hypertension, thinning of bones, cataracts, and increased
infections. These risks are most pronounced when steroids are
taken for long periods of time or at higher doses. Close
supervision by a physician is essential.
A number of other immunosuppressive
drugs are used to treat autoimmune diseases that cause arthritis,
including rheumatoid arthritis, scleroderma, and lupus. Rheumatoid
arthritis traditionally has been treated with drugs that modify the
immune system, such as gold salts, penicillamine, and
hydrochloroquine. More recently, methotrexate has been shown to slow
the progression of rheumatoid arthritis and improve the patient's
quality of life. Methotrexate itself can be highly toxic and
requires frequent blood tests for patients on the medication.
The most recent breakthrough in
rheumatoid arthritis has been the development of so-called "anti-biologics"
that target individual molecules to reduce inflammation. Such
medications, including etanercept (Enbrel) and infliximab (Remicade),
are administered by injection or vein (intravenously) and can confer
dramatic improvements in the patient's quality of life.
SURGERY AND OTHER APPROACHES:
In some cases, surgery to rebuild the joint (arthroplasty) or to
replace the joint (such as a total knee joint replacement) may help
maintain a more normal lifestyle. The decision to perform joint
replacement surgery is normally made when other alternatives, such
as lifestyle changes and medications, are no longer effective.
Normal joints contain a lubricant
called "synovial fluid." In joints with arthritis, this fluid is not
produced in adequate amounts. A relatively recent approach is to
inject arthritic joints with a manmade version of joint fluid known
as hylan G-F 20 (Synvisc). This synthetic fluid may postpone the
need for surgery at least temporarily and improve the lifestyle of
arthritis patients. Many studies are evaluating the effectiveness of
this type of therapy.
LIFESTYLE CHANGES:
Both rest and exercise are important. Warm baths, massage, and
stretching exercises may be helpful. Modifications in daily
activities or using assistive devices to protect the joints are
often recommended.
OTHER THERAPY:
Physical therapy for muscle and joint rehabilitation may be
recommended in severe cases. |